| Uemura M, Miyake T, Uene M, Okumura N, Yakushiji K, Izu M, Tanaka H, Nakashima S, Saito K,Masaki K (2004) Clinical study of fluoride dentifrice on remineralization of incipient lesions. J Dent Res. 83 |
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Objectives: Although there are various studies on remineralization of incipient enamel lesions by fluoride treatments, scarce are the clinical studies to examine the effectiveness of fluoride dentifrice on remineralization of white spot lesions. This study aimed to evaluate the effectiveness of test fluoride dentifrice newly formulated by LION Corporation by use of QLFTM (Quantitative Light-induce Fluorescence, Inspektor Research Systems bv Netherlands). QLFTM system provides objective outcomes of reduced fluorescence intensity at lesion surfaces compared with sound ones. Methods: Informed written consents were obtained from 145 volunteers aged over 10 years old who had at least one white spot lesion on buccal smooth surfaces, and they were enrolled in this study. They were allocated randomly to two groups, one for test dentifrice containing 950 ppm fluoride (sodium), enzyme dextranase and fluoride substantivity enhancer cationic cellulose, the other for placebo control dentifrice without the above ingredients. Basement lesion measurements were performed by QLFTM and either of the test or placebo dentifrice was given to the volunteers. They were reexamined at three, six and twelve months after the basement measurements. Throughout the duration, no other fluoride regimen was allowed. The effectiveness of the test and placebo dentifrice were evaluated by calculating % reduction in maximum fluorescence loss (MaxDF: %) and mineral loss (DQ = "lesion area: mm2"L "mean fluorescence loss: %") from the basement measurement values. Results: Twelve month measurements yielded 31.7% reduction in DQ (p<0.0001) and 15.2% in MaxDF (p<0.01) in the test dentifrice group, whereas no significant reduction was observed in the placebo dentifrice group. Conclusions: This clinical study clearly demonstrated that regular use of the test fluoride dentifrice had ability to substantially remineralize white spot lesions in a year, and the authors think that QLFTM system satisfies significant parts of requirements as a validated diagnostic tool. |