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Carbamide peroxide increases the porosity of the surface layer of white spot caries lesions by decomposing the organic material. Addition of fluoride to the porous surface may enhance its uptake, thereby resulting in more remineralization. The aim of this study was to determine if pretreatment with carbamide peroxide enhances fluoride uptake and fluoride-induced remineralization by APF gel. Caries was induced by a microbial model in vitro. Demineralized specimens were separated into 4 groups and treated for remineralization for 20 days. Groups were as follows: (1) 0 ppm fluoride dentifrice; (2) 10% carbamide peroxide (Opalescence); (3) 1.23% APF gel; (4) 10% carbamide peroxide (Opalescence) and 1.23% APF gel. Group 1 was treated with a cyclic remineralization regimen. Groups 2, 3 and 4 were modified by application of carbamide peroxide and APF gels on the surfaces of the specimens at 2 h and 4 min in order, at the beginning of each treatment. Posttreatment analyses were fluoride biopsy and QLF measurements. Fluoride uptake was found to be statistically significant between the groups (F = 18.806; pd0.0001). Tukey Kramer analysis showed differences between groups 1 and 3, 1 and 4, 2 and 3 and 2 and 4 (pd0.001, pd0.01, pd0.001, pd0.01). QLF ¢Q of remin-demin surfaces (rd) was found to be statistically significant (F = 3.743; p = 0.0134). Tukey Kramer analysis showed differences between groups 1 and 3 and 1 and 4 (pd0.05; pd0.05). QLF ¢Q of remin-sound surfaces (rs) were found to be statistically significant (F = 8.660; p = 0.0002). Tukey Kramer analysis showed differences between groups 1 and 2, 1 and 3, and 1 and 4 (pd0.01, pd0.05, pd0.001). Application of carbamide peroxide gel does not seem to enhance the remineralization process with APF gel under the conditions of this study. |