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Peroxides can increase the permeability of enamel and thereby reduce surface tension on the surface layer of white spot caries lesions. The objective of this study was to determine if pretreatment with carbamide peroxide enhances fluoride uptake and fluoride-induced remineralization. Caries was induced by an in vitro microbial model. Demineralized specimens were separated into four groups and treated for remineralization during 20 days. Groups were as follows: (1) 0 ppm fluoride dentifrice; (2) 1,100 ppm NaF (Crest); (3) 10% carbamide peroxide (Opalescence); (4) 1,100 ppm NaF (Crest) and 10% carbamide peroxide (Opalescence). Groups 1 and 2 were treated with a cyclic remineralization regimen. Groups 3 and 4 were modified by application of carbamide peroxide gel on the surfaces of the specimens at 2 h at the beginning of each treatment. Posttreatment analyses were fluoride biopsy and QLF measurements. Statistically significant differences in fluoride uptake were found between the groups (F = 8.351; p = 0.0002). Tukey Kramer analysis showed differences between groups 1 and 2, 2 and 3, and 2 and 4 (pd0.001; pd0.01; pd0.05). Differences in QLF ¢Q of remin-demin surfaces (rd) were found to be statistically nonsignificant between the groups (F = 1.966; p = 0.1363). QLF ¢Q of remin-sound surfaces (rs) were found to be statistically significant between the groups (F = 15.208; pd0.0001). Tukey Kramer analysis showed differences between groups 1 and 3, 1 and 4, 2 and 3, and 2 and 4 (pd0.001; pd0.001; pd0.05; pd0.001). The applicaton of carbamide peroxide gel does not seem to enhance remineralization with NaF dentifrice under the conditions of this study. |